Comment by breatheoften

I think heterogeneous computing is actually coming this time. Increasing binary size requirements wherever portability is required will be an intended sacrifice toward that aim (but for app store based distributions - the only place required to pay the binary size tax will be in the size of the bundle provided to the app store vendor).

I think the importance of ISAs will fade away generally in favor of specifications that enable coordination of higher level memory model semantics "across" compute resources -- the cpu/compute core becomes the thing that allows you to share reads and transfer write ownership of memory as efficiently as possible between heterogeneous components that operate on the compute graph -- and many of these compute components may require various binary forms of task specific instruction encoding ...