Comment by throwaway2331

Old FDA data.

Here's the latest: https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/02...

> 12.3 Pharmacokinetics

> Metabolism Lisdexamfetamine is converted to dextroamphetamine and l-lysine primarily in blood due to the hydrolytic activity of red blood cells after oral administration of lisdexamfetamine dimesylate. In vitro data demonstrated that red blood cells have a high capacity for metabolism of lisdexamfetamine; substantial hydrolysis occurred even at low hematocrit levels (33% of normal). Lisdexamfetamine is not metabolized by cytochrome P450 enzymes.

EDIT: A better one: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257105/