Comment by jsmith45

> Lactose is a specific, well-understood example of some people absorbing nutrients much better than others. I think there are other examples, and I expect there's a lot of variation in absorption efficiency that's less known. When you hear about people who eat lots of food and remain thin, I suspect this is part of the explanation. And whether their bacteria get the calories instead, or whether it passes through untouched, might show up in CO2 measurements but I don't think it would be related to body fat accumulation.

Yeah, the blind assertions I have seen that people basically always absorb pretty much 100% of the calories of the food is weird. We already know that some forms of calories like fiber have very low absorption rate. The Atwater indirect system of calculating calories takes that into account, but is still just an estimation, since it uses average calorie values for protein, carbs, and fat.

And so I've just noted that calories on packaging is just an approximation. An individual food may actually have more above average proteins than below average, etc, which can skew the real calorie count. For example, nuts are known to have less calories than indicated on the label, with whole almonds having 20% fewer. (https://doi.org/10.1093/jn/138.9.1741S) This is also ignoring the fact that many foods, especially those prepared by people are not always super consistent in sizing. A subway sandwich prepared correctly should on average have the calories subway claims, but we all know that some locations will follow the correct procdure more closely than others. Etc.

The other issue with just blindly going with calorie counting (which is really on tracking calories in) is that the differences in the calories one takes in will cause changes in the calories one expends. Eating fairly substancially less than your body is used to will almost certainly cause one to feel bad, and avoid doing as much, meaning fewer calories out, at least partially offsetting the the calorie reduction. But people are generally not measuring the calories expended very closely, if they bother doing it at all.