Comment by Terry_Roll

Depending on "who" you listen to Wild Lettuce is either no good or its better than morphine without the addiction. https://en.wikipedia.org/wiki/Lactuca_virosa https://erowid.org/plants/lactuca/lactuca.shtml

https://en.wikipedia.org/wiki/Lactucarium#History

So with man made chemicals they tend to not break down as easily, you see this with man made pesticides like pyrethrin's yet the pyrethrin's in Chrysanthemum do break down easily, organophosphates (nerve agents at the right dose) are another group used to dip Sheep in, but might show up in trace amounts in lanolin based Vit D3 supplements.