Comment by wtallis

You end up allowing first-party scripts from most sites that you frequent (except the ones that don't actually require it for basic functionality, but use it to implement anti-features), leaving third-party scripts disabled most places. After you've been browsing this way for a month or two and your ruleset is reasonably populated, the annoyances are almost entirely with clicking random links on HN and Reddit; often, I decide a poorly-accessible site probably wasn't worth my time anyways, but I'll reconsider if the comments indicate otherwise.