Comment by nybble41

Native resolution at 10bpp requires 40% less data per frame than the final Full HD RGB output at 8bpp per channel (24bpp total), so it would represent some savings.

The problem is that neither format fits within the limits of USB 2.0 at 15 FPS or higher. To achieve a reasonable framerate you need to apply compression, and generally speaking you'll get better compression if you demosaic first.