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Comment by adamredwoods

3 years ago

Car-T seems promising for leukemia and lymphoma, but not as efficacious in solid tumors:

https://www.lls.org/treatment/types-treatment/immunotherapy/...

Also 2nd gen BTK inhibitors:

https://en.wikipedia.org/wiki/Acalabrutinib

https://en.wikipedia.org/wiki/Bruton%27s_tyrosine_kinase

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adamredwoods

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elhudy  3 years ago

BTK inhibitors are technically in 3rd gen (noncovalent) already if you can get in the trials (which are very promising considering they use the same mechanism).