Comment by panabee

as an outsider learning more about protein folding, could you elaborate on the assertion that the sequence is (mostly) all you need (transformer/ML reference intended).

doesn't this assume the final fold is static and invariant of environmental and protein interactions?

put another way, how do we know that a protein does not fold differently under different environmental conditions or with different molecular interactions?

i realize this is a long-held assumption, but after studying scientific research for the past year, i realize many long-held assumptions aren't supported by convincing evidence.