Comment by zzo38computer

I suppose that Win32 can be helpful if you want to make programs that run on both Windows and on Linux (and also ReactOS, I suppose), but might not work as well for programs with Linux specific capabilities.

(Also, I have problems to install Wine, due to package manager conflicts.)

There are other possibilities, such as .NET (although some comments in here says it is less stable, some says it works), which also can be used on Windows and on Linux. There is also HTML, which has too many of its own problems and I do not know how stable HTML really is, either. And then, also Java. Or, you can write a program for DOS, NES/Famicom, or something else, and can be emulated in many systems. (A program written for NES/Famicom might well run better on many systems than a native code does, especially if you do not do something too tricky in the code (in which case some implementations might not be compatible).) Of course also the different ways they have different advantages and disadvantages, with compatibility, efficiency, capability, and other features.