Comment by davesque

I think your reply gets at the answer to my own question that I tend to lean towards. And that is that craving further concepts is an inherent problem that follows from being a thinking being. What you say seems like part of the answer, which is that one needs to make a conscious decision not to be bothered by the fundamental lack of a justification for reality. Just focus on what your knowledge enables you to do. But it still seems sad on some level that we're "condemned" to coast through this world that is so rich in detail but seemingly lacking in purpose.