Comment by morelisp

I have worked on networked projects ranging from modern datacenters to ca. 2005 consumer-grade ADSL in Ohio to cellular networks in rural South Asia.

There are situations where you want Nagle's algorithm on; when you have stable connections but noisy transmission, streams of data with no ability to buffer, and no application-level latency requirements. There are not many such situations. It is not any of these, and it's certainly not within any datacenter.