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Comment by 2fast4you

2 years ago

Not an expert, but couldn’t the mRNA vaccine target only part of the virus genome that’s stable across mutations/variants? That would give you a broad vaccine resistant to mutations

Stable across mutations? On what timeframe.. Its been stable so far.

However, create a population with narrow immunity based on a single protein, and you create a selection pressure that incentivizes mutations in that protein. Once a successful mutation exists, it has a wide open field to spread unchecked. With broad immunity (multiple proteins) it is much less likely that a variant can realize the multiple simultaneous mutations that would be required to spread effectively.