Comment by mananaysiempre

The literal answer is yes, an ATA TRIM, SCSI UNMAP, or NVMe Deallocate command can cover whatever range on a device you feel like issuing it for. (The device, in turn, can clear all, none, or part of it.) On Linux, blkdiscard accepts the -o, --offset and -l, --length options (in bytes) that map more or less exactly to that. Making a(n unformatted) partition for the empty space and then trimming it is a valid workaround as well.

But you’re most probably doing this on a device with nothing valuable on it, so you should be able to just trim the whole thing and then allocate and format whatever piece of it that you are planning to use.