Comment by makeitdouble

If you app is in the App store or Google Play store, you'll have to care about the EU the moment you open your app to EU users. Not complying will either get you removed from the EU store or get your whole account banned, US included, depending on how bad the store owner feels about you.

If you take direct payments, you'll probably have a talk to your card acquirer on how they feel about EU clients and how you deal with them. They might decide to not do any business with you depending on that.

In these above examples, I think having wider scale actually helps negotiating better terms instead of getting kicked out at the first occasion.