Comment by A_D_E_P_T

Okay, I have a wild idea for you.

You need adventure.

As others have said, you also need a hobby.

Consider how rapamycin was discovered, by scientists traveling to distant Rapa Nui and sampling soil. There are lots of truly wild places left on Earth -- most of Papua New Guinea, the northwestern Bolivian Amazon, the deep interior of the DRC, to name but few -- places where civilization has yet to touch. Go out there, discover new plant and insect species, and fingerprint plant and soil samples. You might find some very interesting and commercially-useful small molecules. But, more importantly, it would be a lot of fun.

You'd need a team, but that shouldn't be too difficult to assemble.

It's what I would do if I had absolute freedom.