Comment by timewizard

The flight control loops are strongly latched. They are constantly checking the state of discretes, control surfaces, and intended guidance. If any critical parameter gets out of range for a period of time or if any group of standard parameters gets out of range the vehicle will simply cease powered flight.

In the Space Shuttle, given that it was human rated, the "Range Safety" system was completely manual. It was controlled by a pair of individuals and they manually made the call to send the ARM/FIRE sequence to the range safety detonators.