Comment by Earw0rm

I wonder what energy-saving optimisations the human body has which lead to worse outcomes in our energy-rich environment.

I don't just mean fat storage algorithms leading to metabolic syndrome and T2D, but for example whether we could afford to have better immune and musculoskeletal systems, more cancer-fighting cells, better regeneration etc if we were tuned to an energy budget of 3000kcal instead of 2000kcal.