Comment by 00N8

A lot depends on the actual reactor design.

I was thinking more of large scale D-T fusion, e.g. the tokamak design, which requires breeding tritium & is expected to create a lot of neutron activated waste. The tritium is especially concerning, as it's roughly as deadly as polonium-210 & highly bioavailable in the form of super heavy water.

You're probably right for smaller aneutronic designs like Helion's. If they can actually be made to work, they'll be much safer.