Comment by TimorousBestie

I’m neither an epidemiologist nor a statistician (just a mathematician pretending to be a coder and/or butterfly), but I do not believe there are no mathematical tools to mitigate the statistical impact of comorbidities and accidental misreporting.

To contextualize this: my position is “weak signals are possible even with noisy data”; I read your response as “but the data is really noisy,” which, sure, agreed; the user I was responding to seems closer to the solipsistic position “there is effectively no data at all.”