Comment by cjbgkagh

ME/CFS shows up as immune system dysfunction and for most people is likely downstream from dysautonomia. Given the huge overlap of people with long covid and hEDS, and that long covid presents as dysautonomia, the math likely works out that most people with ME/CFS actually have hEDS. It’s massively underdiagnosed. It’s likely one of many TNXB SNPs, these are overlooked for a few main reasons - it’s considered too common for a rare condition and it’s hard to sequence and only detectable with modern high quality deep WGS.

The other thing is that GLP-1As actually do appear to help with autoimmune conditions and has been, in my case and in the case of many others, one of the most effective medications for treating ME/CFS.

I wish it was a lack of a profit motive that caused medical researchers to be so off base but it appears what is more likely that they’re not very good with stats, as being good at stats would get in the way of all the ‘accidental’ p-hacking they’re so addicted to.

Edit: Added an email to my hacker news user details