Comment by vermilingua
8 months ago
It may be worth noting that antidepressant medication has a strong suppressing effect on psychedelics.
8 months ago
It may be worth noting that antidepressant medication has a strong suppressing effect on psychedelics.
Depends on the type! Generally might be true for SSRIs but not always for TCAs or lithium which can have the opposite effect. https://pubmed.ncbi.nlm.nih.gov/8788508/ (just one example)
Well aware and accounted for.
If they’re doing high doses of psychedelics and only experiencing a body high, then they’re either on a drug blocking its effects, or they’re not taking a 5HT2-A agonist. They simply do not just produce a body high at high doses, you will know when you’re tripping.
This isn't completely true. Tolerance to psychedelics is a thing, and can often ve extremely long lasting. I have a friend that when given heroic doses of 2C-B(50mg or more, orally), hardly experienced more than threshold level effects. This was 2C-B tested and confirmed to have 95% purity, and it affected me exactly as expected. He was not on any drugs except hash, which is typically synergistic.
In his case, according to him he yad used 2C-B very heavily many years previously, and it seems he developed an extremely high level of tolerance which remained unchanged for many years of non-use.
In the cases discussed in the thread, it's possible that something similar was happening. Indeed, many antidepressants also alter serotonin receptor expression over time, and it's plausible that in some people, these effects could linger for a long time.
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Imagine being on a med for 30-50 years.
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