Comment by mtlmtlmtlmtl
8 months ago
I'd be interested to see those studies. I think there could be a couple different types of tolerance, one of which only occurs with rather heavy use. It's something I've seen reported anecdotally from a number of people who've used psychedelics very heavily. It might not show up in human studies because of ethical concerns. There could be some interesting pharmacological differences too, where this only occurs with specific drugs. The psychedelics are quite varied in terms of pharmacodynamics beyond just the 5-HT-2 receptor subfamily.
Here's the OG tolerance study done on psilocybin and LSD: https://link.springer.com/article/10.1007/BF00407974
We need more studies on the long term effects of heavy psilocybin use. We know how chronic use of alcohol and cannabis affect people fairly well at this point. We also know a lot about regular psilocybin use, but not a whole lot about what happens to people if they take it for 20 years.