Comment by cess11

With 5-HT2a psychedelic substances you get an immediate, extreme tolerance so unlike ethanol or other common GABA:ergics you won't get that kind of every day abuse and related self harm.

Single dose use is more likely to be harmful with ethanol at a comparable degree of intoxication, it is strongly disinhibitory in comparison, but a particular person might be more sensitive one way or the other.