if you are HIV negative, have had anal or vaginal sex in the past 6 months, and:
Have a sexual partner with HIV (especially if the partner has an unknown or detectable viral load), or
Have not consistently used a condom, or
Have been diagnosed with a sexually transmitted infection (STI) in the past 6 months.
This is a very, very high number of candidate patients! Anyone who inconsistently uses a condom. "During 2011–2015, 14.8 percent of women and 19 percent of men aged 15–44 reported that they used a condom ‘every time’ they had intercourse in the past 12 months,” the NCHS team wrote in their report." [1]
A wide net can be cast, but broadly speaking, you’ll want to start with your highest exposure and compliance (having to take a pill everyday is not great) risk patients first and work your way down as you scale up manufacturing and last mile infrastructure. Daily pill users turn into twice annual injection users, healthcare workers who could receive the injection at the workplace, etc.
This should, in theory, cause the infection rate to rapidly decline when you disrupt the most common and frequent transmission vectors. The slow long burn is going to be upkeep on all of this until HIV is eradicated (similar to the last days of a disease due to sufficient vaccination uptake, think smallpox).
thanks for that link.
if you are HIV negative, have had anal or vaginal sex in the past 6 months, and:
This is a very, very high number of candidate patients! Anyone who inconsistently uses a condom. "During 2011–2015, 14.8 percent of women and 19 percent of men aged 15–44 reported that they used a condom ‘every time’ they had intercourse in the past 12 months,” the NCHS team wrote in their report." [1]
[1] https://www.nbcnews.com/health/health-news/third-u-s-men-use...
A wide net can be cast, but broadly speaking, you’ll want to start with your highest exposure and compliance (having to take a pill everyday is not great) risk patients first and work your way down as you scale up manufacturing and last mile infrastructure. Daily pill users turn into twice annual injection users, healthcare workers who could receive the injection at the workplace, etc.
This should, in theory, cause the infection rate to rapidly decline when you disrupt the most common and frequent transmission vectors. The slow long burn is going to be upkeep on all of this until HIV is eradicated (similar to the last days of a disease due to sufficient vaccination uptake, think smallpox).