Comment by trehalose

I vaguely recall reading that as a rule of thumb, mouse doses of various drugs tend to be equivalent to around ten times higher than human doses in terms of mg/kg. (Don't quote me on that.)

It's not true that there's no overdose risk with psychedelics. Ones that are partial agonists of the serotonin 2A receptor, like LSD and psilocybin, are fairly safe, physiologically. Psychedelics that are full agonists of that receptor, like NBOMe- phenethylamines (which are commonly sold as LSD!), can be deadly vasoconstrictors at dosages not far beyond a pleasant dose. They have killed people. Anyone taking "LSD"/"acid", who didn't make it themself, should be aware of this.