Comment by bmillare

To me this paper confuses regulation via mitochondria from the requirement of sleep. Even if experimentally manipulating mitochondria state induces sleep, this might just be a proxy indicator control mechanism. ETC leak is only an issue for these dFBNs which are specifically complementary active to normal neuronal cells. I would say mitochondria are important for sleep regulation but this is specific to animals with brains. Other kingdoms do not "sleep". This is too much a stretch to say mitochondria dysfunction is the cause of sleep when other kingdoms also have mitochondrial stress and don't have actual analogical "sleep" processes. My raw take given my PhD work was on mitochondria.