Comment by cpncrunch

No well replicated studies.

>they seem to function differently

Except there isn't evidence showing this.

>5 tried to check for differences in mitochondrial respiration between ME/CFS patients and healthy controls, and 4 of the 5 found notable differences

But did they look at the same thing? I also don't think that includes all the studies that failed to show mitochondrial differences, and failures to replicate previous studies.

There is the recent Ryback study (currently a preprint) which failed to replicate Fluge and Mella's result, and showed no difference from controls. There is the Tomas study which showed no difference in the ATP profile test from controls. Also, a 2019 Tomas study showed no difference in respiration between patients and controls.