Comment by pmarreck

One contributing factor to human weight gain when given a non-limited supply of food is apparently the knocking-out of the gene that produces uricase, which pretty much every other animal has (and they usually don't get fat, even when given unlimited food supply). Not a single human has a working uricase gene. It has been hypothesized that famines throughout human history (there's your "evolutionary pressure") have contributed to this.

My point is that selection pressures do not always lead to optimal outcomes...

https://chatgpt.com/share/688e4822-4e44-8004-9625-21a254fa02...