Comment by datadrivenangel

250 million probably gets you a couple of research labs and incremental field advances per year?

Assuming a lab has 20 phds/postdocs and a few professors, call it 25 people per lab, and you're compute / equipment heavy, getting you up to an average of 1M per person per year in total fully loaded costs (including facilities overhead and GPUs and conferences and whatnot), then you're looking at 200 PhD researchers. Assuming that each PhD makes one contribution per 4 years, then that's 50 advances in the field per year from your lab. if only 10% are notable, that's 5 things you've gotten that people are going to get excited about in the field. You need 2% of these contributions to be groundbreaking to get a single major contribution per year.

So 250M for a single person is a lot, but if that person is really really good, then that may be only expensive and not insane.