Comment by orphea

If it doesn't have to be VB.NET, then JetBrains Rider (free for non-commercial development) + C# + Avalonia as the GUI framework will bring you the closest to your "best" way.

If it does, this SimpleIDE might be an option but also it might be so that the only good option would be Visual Studio... which requires Windows. But switching to it will give you two more options - WinForms and WPF - both are old but tested GUI frameworks.