Comment by JPLeRouzic

> "why only tumor cell react to PAMP instead of healthy cells"

I am not a scientist, but I believe that "normal" cells do not seek long-chain alien sugars like those produced by ocean bacteria. Conversely, "cancerous" cells may find these uncommon sugars appealing, and they consume sugar eagerly (Warburg effect).

After the alien sugars are metabolized, fragments migrate to the cell membrane and might be recognized by the immune system as foreign.

The fact that large molecules trigger Pyroptosis may be helpful.