I don’t want to spoil anything for you, but ethanol is actually a very reactive molecule — and in some ways, it acts similarly to opioids like heroin. It, among other things, stimulates endogenous opioid pathways, leading to the release of β-endorphins and activation of mu-opioid receptors. So, alcohol works indirectly, heroin directly – but both enhance opioid signalling. If you’re curious, this study explains it really well:
Food activates it within normal biological limits, alcohol and heroin artificially push the same system far beyond normal range, forcing the brain to compensate by downregulating receptors or reducing endogenous opioid production, so it's totally legit to compare alcohol to heroin
I don’t want to spoil anything for you, but ethanol is actually a very reactive molecule — and in some ways, it acts similarly to opioids like heroin. It, among other things, stimulates endogenous opioid pathways, leading to the release of β-endorphins and activation of mu-opioid receptors. So, alcohol works indirectly, heroin directly – but both enhance opioid signalling. If you’re curious, this study explains it really well:
https://pmc.ncbi.nlm.nih.gov/articles/PMC3728478/
Food can also indirectly enhance opioid signaling. What's your point?
Food activates it within normal biological limits, alcohol and heroin artificially push the same system far beyond normal range, forcing the brain to compensate by downregulating receptors or reducing endogenous opioid production, so it's totally legit to compare alcohol to heroin
I think they are legitimately mocking the notion that we wouldn't all be better off without alcohol.