Comment by energy123

This is why Markowitz isn't used much in the industry, at least not in a plug-and-play fashion. Empirical volatility, and the variance -covariance matrix more generally speaking, is a useful descriptive statistic, but the matrix has high sampling variance, which means Markowitz is garbage in garbage out. Unlike in other fields, you can't just make/collect more data to reduce the sampling variance of the inputs. So you want to regularize the inputs or have some kind of hybrid approach that has a discretionary overlay.