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Comment by roughly

3 hours ago

Epigenetics is one of those things that seems wild until you pull the camera back a bit. A cell is affected by and responds to its surroundings - this is not controversial. In eukaryotes, this is usually done by way of altering gene expression - up- or down-regulation by means of chemical markers on the cell’s DNA which are created or removed by enzymes which are activated or deactivated by certain substances in the cell or its environment - in other words, the cell’s environment affects gene regulation within the cell by traceable mechanisms*. All cells, save at least one, are descendent of other cells, and cells split by meiosis, in which the chemical environment within and without the cell is shared by the “descendent” cell - so of course this happens with human embryos as well. Of course the expression of your genes is affected by what happened to your parents (well, your mother, at least), because gene expression is affected by what happens to a cell and you are made up of a lineage of cells descended from your mother’s cells. If you ask how one organism could be affected by something it didn’t experience, sure, that could be a quandary, but looking at a line of cells and wondering how later ones could be affected by environmental pressures on earlier ones isn’t nearly as much of a mystery, and we’re all just extended cell lineages.

(As if first time mothers didn’t have enough to worry about - stop stressing so much, it could lead to long-lasting irreversible changes to your fetus!)

* Standard biology disclaimers: this is not the only way this happens, this varies across species and time, nature has no master plan. “Some of the time some genes have some amount of their expression modified somewhat by some mechanisms that are somewhat responsive to some part of the cell’s environment sometimes.”

>>> (As if first time mothers didn’t have enough to worry about - stop stressing so much, it could lead to long-lasting irreversible changes to your fetus!)

This is plainly not plausible. "Irreversible" doesn't play well with the length of time humans have been a thing.

  • Ask a parent what they hear when they hear “irreversible” in conjunction with their child. I promise nobody mistook that for “until the heat death of the universe,” but I can add a note if you really think it’s warranted.

    • You definitely make a good point.

      But even reversible changes aren’t always “reversed”. They aren’t necessarily minor.

      Sure, breaking an arm or skipping high school can be a “reversible” change. But not often not fully “reversed” and/or not done so in a negligible time frame. There are costs. Seems like biological development could be similar.

Great writeup!

And as someone less knowledgeable about biological sciences than others, I think learned even more from your disclaimers!

p.s. If you know any good sources for adults to catch up on some biology basics, let me know.

Does meiosis involve a reset mechanism of any kind?

  • no, no it does not strip protien complexes away from the DNA strand.

    it involves a localized progression along the DNA surrounded by histones, and regulatory enzymes, displaced from proximity, until the replication fork zooms on through, and it all snaps back together.

    the process is error prone, strands may cross over, chromosomes may fail to migrate properly.