Comment by cheald

In regards to obesity and fat loss, smooth, consistent weight loss is essentially always preferable to rapid weight loss - both from a whole health standpoint, and from a durability-of-effect standpoint - and sooner is always better than later.

IMO, the ideal way to use these is as an enabler or multiplier for a healthy lifestyle. Using GLP-1-family drugs to enable an unhealthy lifestyle is always going to work out worse for everyone than using them as an adjunct to disciplined diet, regular exercise, and good sleep.