Comment by neom

This article lead me to an interesting exchange about vitiligo, thought I'd post it here for posterity:

Me - Nov 28, 2025, 10:51 AM:

Hey Dr. Dadachova, there was an article in the bbc today about radiotrophic fungus, I did some reading on them and it got me thinking about vitiligo. Current dermatology literature focuses on the immune destruction of melanocytes, often citing "oxidative stress" as a cause. However, there seems to be a total absence of data regarding the physical structure of the melanin polymer itself in these patients.

re: your findings that melanin’s electronic structure (EPR signal) changes under stress to become "protective/radiotrophic," I am wondering if the inverse mechanism could be driving vitiligo, where the melanin polymer is structurally defective (acting as a pro-oxidant "leaky capacitor") rather than a protective shield?

To your knowledge, has anyone ever applied the EPR techniques used in your fungal research to analyze melanin isolated from the active border of Vitiligo lesions? It seems plausible that a structural defect in the polymer physics could be the upstream trigger for the autoimmunity, similar to the "toxic melanin" theories in Parkinson’s disease.

I realized this sits at the exact boundary of your expertise in melanin physics and clinical pathology, and I was curious if you had ever explored this link??

tnx for reading! have a great weekend! :)

j.

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Dadachova, Kate Fri, Nov 28, 9:57 PM to me

Hello John,

Thank you for your message and interest in melanin work! We have never looked at melanin in Vitiligo lesions but I think that your hypothesis about defective melanin could be correct. I know that there are studies showing absence of EPR signal in Vitiligo, and, on the contrary, enhanced melanin signal in melanoma in comparison with benign nevi. Probably an interesting study for a pathologist to perform!

Best regards,

Kate