Comment by nine_k

There is no way to reliably block pop-ups in the general case.

The working way is to block ad networks entirely, because online ads have become unreasonably obnoxious. A web site that critically depends on ads may state so, and refuse to run with ads blocked. (When a site I need says that, I disable my ad blocker. If a site I don't need does that, I close the tab.)

I do believe that good web sites deserve support; I may offer a donation if there is an easy way to do so. I don't mind the donation pop-up on python.org, and even in Wikipedia.

If a site only exists for the purpose of making money off ads, not because the owners care about the content, and the visitors don't care enough either to tolerate ads, then I don't see the shutdown of such a site a big loss.