Comment by saalweachter

So, regarding books, why do you think the methods of printing books varies based on the size of the printing sheets?

Regardless of the size of your printing sheet, you choose a page size that's based on dividing your printing sheet in half N number of times, typeset your document to that page size (which you can't even skip for ISO paper sizes, because you pick your font size independent of the paper sizes), print 2^N pages per printing sheet in a particular pattern, fold and/or cut the sheet up, and bind.

There's no difference in waste or time regardless of your paper size choices, unless you do something silly or artistic, like choosing to print a square book or some shape not derived from halving your paper size.