Comment by FireBeyond

Table sugar is "bad". HFCS is worse.

- https://pubmed.ncbi.nlm.nih.gov/23181629/ - countries with higher HFCS availability had higher T2D prevalence, and the association persisted after adjusting for country-level BMI and other factors.

- https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1... - randomized trial in overweight/obese adults comparing diets including HFCS vs comparator sweeteners under structured conditions

> Glucose and Fructose often go together in your body, so the signal would be there. In your gut, sucrase breaks sucrose (table sugar) into glucose and fructose. In drinks, when sucrose is exposed to CO2 and other acids it turns into fructose and glucose before it hits your gut!

Nothing in this contradicts me. But the more fructose versus glucose, the more hepatic processing, and the fewer hormonal signals, leading to increased ingestion.

It's not that one is objectively "bad and only bad", its that our metabolism is not tuned to such a heavy fructose vs glucose ratio.