Comment by biophysboy

> look at any HN thread on the topic of fraud in science.

HN is very tedious/lazy when it comes to science criticism -- very much agree with you on this.

My only point is replication is necessary to establish validity, even if it is not sufficient. Whether it gives a scientist a false sense of security doesn't change the math of sampling.

I also agree with you on quality issues. I think alternative investment strategies (other than project grants) would be a useful step for reducing perverse incentives, for example. But there's a lot of things science could do.