Comment by raddan
15 hours ago
Ugh, wow, somehow I missed all this. I guess he joins the ranks of the scientists who made important contributions and then leveraged that recognition into a platform for unhinged diatribes.
15 hours ago
Ugh, wow, somehow I missed all this. I guess he joins the ranks of the scientists who made important contributions and then leveraged that recognition into a platform for unhinged diatribes.
Please don't lazily conclude that he's gone crazy because it doesn't align with your prior beliefs. His work on Covid was just as rigorous as anything else he's done, but it's been unfairly villainized by the political left in the USA. If you disagree with his conclusions on a topic, you'd do well to have better reasoning than "the experts said the opposite".
Ioannidis' work during Covid raised him in my esteem. It's rare to see someone in academics who is willing to set their own reputation on fire in search of truth.
What’s happening here?
“Most Published Research Findings Are False” —> “Most Published COVID-19 Research Findings Are False” -> “Uh oh, I did a wrongthink, let’s backtrack at bit”.
Is that it?
Yes, sort of. Ioannidis published a serosurvey during COVID that computed a lower fatality rate than the prior estimates. Serosurveys are a better way to compute this value because they capture a lot of cases which were so mild people didn't know they were infected, or thought it wasn't COVID. The public health establishment wanted to use an IFR as high as possible e.g. the ridiculous Verity et al estimates from Jan 2020 of a 1% IFR were still in use more than a year later despite there being almost no data in Jan 2020, because high IFR = COVID is more important = more power for public health.
If IFR is low then a lot of the assumptions that justified lockdowns are invalidated (the models and assumptions were wrong anyway for other reasons, but IFR is just another). So Ioannidis was a bit of a class traitor in that regard and got hammered a lot.
The claim he's a conspiracy theorist isn't supported, it's just the usual ad hominem nonsense (not that there's anything wrong with pointing out genuine conspiracies against the public! That's usually called journalism!). Wikipedia gives four citations for this claim and none of them show him proposing a conspiracy, just arguing that when used properly data showed COVID was less serious than others were claiming. One of the citations is actually of an article written by Ioannidis himself. So Wikipedia is corrupt as per usual. Grokipedia's article is significantly less biased and more accurate.
He published a serosurvey that claimed to have found a signal in a positivity rate that was within the 95% CI of the false-positive rate of the test (and thus indistinguishable from zero to within the usual p < 5%). He wasn't necessarily wrong in all his conclusions, but neither were the other researchers that he rightly criticized for their own statistical gymnastics earlier.
https://statmodeling.stat.columbia.edu/2020/04/19/fatal-flaw...
That said, I'd put both his serosurvey and the conduct he criticized in "Most Published Research Findings Are False" in a different category from the management science paper discussed here. Those seem mostly explainable by good-faith wishful thinking and motivated reasoning to me, while that paper seems hard to explain except as a knowing fraud.
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> So Wikipedia is corrupt as per usual. Grokipedia's article is significantly less biased and more accurate.
I hope this was sarcasm.
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Does the IFR matter? The public thinks lives are infinitely valuable. Lives that the public pays attention to. 0.1% or 1%, it doesn’t really matter, right, it gets multiplied by infinity in an ROI calculation. Or whatever so called “objective” criteria people try to concoct for policymaking. I like Ioannidis’s work, and his results about serotypes (or whatever) were good, but it was being co-opted to make a mostly political policy (some Republicans: compulsory public interaction during a pandemic and uncharitably, compulsory transmission of a disease) look “objective.”
I don’t think the general idea of co-opting is hard to understand, it’s quite easy to understand. But there is a certain personality type, common among people who earn a living by telling Claude what to do, out there with a defect to have to “prove” people on the Internet “wrong,” and these people are constantly, blithely mobilized to further someone’s political cause who truly doesn’t give a fuck about them. Ioannidis is such a personality type, and as you can see, a victim.
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Yeah, and lucky you! You gain all this insight b/c you logged into Hacker News on the very day someone posted the truth! What a coincidence!