Comment by Zambyte

You can just visit https://repology.org/ and see that GNU Guix has the 5th largest repository, ahead of Fedora and Gentoo. This does not include any proprietary packages, which can be added using https://gitlab.com/nonguix/nonguix (though gitlab seems to be dying for me right now?)

I've been running GNU Guix for five years now, after lots of distro hopping, including to and from NixOS. I left Nix because I found the documentation (particularly regarding the language) to be a struggle to work with (though I imagine it's improved since then).

GNU Guix + nonguix + flatpak is perfectly suitable for everyday use.