Comment by htek

The problem with antidepressants are that while we know, more or less, what they do, we don't know why they work for some and not for others. Escitalopram (Lexapro) was a vast improvement for me over Citalopram. Then it plateaued and a year later, left me anhedonic. Tried an SNRI that would give me brain zaps every day a few hours before my next dose and it was horrendous to quit using. It also messed with my ability to meditate for a long while. Basically, I could put myself in a mental state that would trigger the same kind of painful brain zaps that withdrawal from the SNRI caused.