Comment by zozbot234

The weird thing about this is that interstellar space ought to actually be very hospitable to cold, highly efficient computational substrates. (This is for standard thermodynamic reasons: reliable computation must be free of noise, and low-temperature means low noise.) So there might be 'life' of a sort in interstellar space that's extremely smart and naturally long-lived compared to humans or even ordinary room-temperature AIs, but just can't do all that much in the outside world (i.e. has very low agency), except very slowly and with exceptional effort.

(Of course, these same constraints apply in a relative sense to the outer regions of planetary systems.)