Comment by JumpCrisscross
8 days ago
> this review reports bioavailability of up to 70% for some agents
To save us some skimming, could you specify which ones? (The review covers cyclic peptides that are absorbed by all mammals.)
8 days ago
> this review reports bioavailability of up to 70% for some agents
To save us some skimming, could you specify which ones? (The review covers cyclic peptides that are absorbed by all mammals.)
There are several - I’m not sure why you say cyclic peptides are somehow distinct from other peptides regarding their bioavailability?
All peptides face similar challenges with absorption; the cyclic peptides simply have less liability to proteolysis.
The text covers dozens of agents with varied biochemical properties.
> I’m not sure why you say cyclic peptides are somehow distinct from other peptides regarding their bioavailability?
I'm saying there are peptides on that list that are bioavailable to non-human mammals.