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Comment by hinkley

5 days ago

Given the multiplicative effect of sedatives and depressants, do you have to factor in inebriation, for instance for a DUI in the ER? Or are the safety margins sufficient?

Generally additive, not multiplicative, and we are used to it. “Titrate to effect” is pretty standard in anesthesia, and we are watching you far more closely than average. Continuous monitoring of oxygenation, breathing, and cardiac rhythm, with no more than 5 minutes between blood pressure readings.