Comment by fsh

This is great!

Input: The first paragraphs of the Watson and Crick paper [1].

[1] https://www.nature.com/articles/171737a0

Output (minus a lot of emojis): BIG NEWS: We’re excited to share a game-changing structure for the salt of deoxyribose nucleic acid (D.N.A.)! This model introduces some truly novel features that are going to have a massive impact on the biological space.

We know Pauling and Corey previously proposed a model (shoutout to them for sharing the manuscript early! ), but after a deep dive, we found a few pain points:

1. The X-ray data suggests it’s a salt, not a free acid—without those hydrogen atoms, the structure just doesn't hold up under pressure.

2. Some of those van der Waals distances are a bit too tight for comfort.

Fraser also suggested a three-chain approach, but it was a bit too "vague" for us to provide actionable feedback on.

So, we’re pivoting to something radically different: A double helix! Two helical chains coiled around the same axis. We’re talking: Phosphate di-ester groups Right-handed helices Bases on the inside, phosphates on the outside (optimized for cation access! )

The structure repeats every 10 residues (34 A), keeping everything perfectly aligned. We’re leaning into the standard configuration to ensure maximum stability and biological interest.

The future of genetics is here. Let’s disrupt the fibre axis together! #DNA #Innovation #Biology #Science #DoubleHelix #GameChanger