That's not replication, that's polymerization. There's nothing template-directed about it, and as far as I can tell the experiment depends on pure initial conditions (the guanosine monophosphate is not mixed with a plethora of other chemicals that could copolymerize with it.)
That purity is the kind of artificiality I was talking about. A bad habit of OoL research is to show that some chemical shows up in trace amounts, then starting the next stage of experiments with a pure batch of that chemical. Robert Shapiro in his 1986 book "Origins" had some very biting things to say about this (the book is not nice to creationists either, btw.)
Again, implausible purity there. I'll add the tetramers used as the components are also much larger than the nucleotides in the Ryugu paper, so would be present in much lower concentrations.
That's not replication, that's polymerization. There's nothing template-directed about it, and as far as I can tell the experiment depends on pure initial conditions (the guanosine monophosphate is not mixed with a plethora of other chemicals that could copolymerize with it.)
That purity is the kind of artificiality I was talking about. A bad habit of OoL research is to show that some chemical shows up in trace amounts, then starting the next stage of experiments with a pure batch of that chemical. Robert Shapiro in his 1986 book "Origins" had some very biting things to say about this (the book is not nice to creationists either, btw.)
Once you have that initial polymerization, thats it, game over, now you can template right off that.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7496532/
Again, implausible purity there. I'll add the tetramers used as the components are also much larger than the nucleotides in the Ryugu paper, so would be present in much lower concentrations.