Comment by SAI_Peregrinus

Personally I only care when distinguishing individual letters matters. So things like paths, URIs, passwords, math, & email addresses should be in a font with as few 'confusable' letters as possible. E.g. variables a & α in an equation should look different, I, 1, & l should look different, 0, o, and O should look different, etc. These are almost always easily distinguishable in serif typefaces, and often indistinguishable in sans-serif typefaces, so I tend to prefer using serif typefaces as a default fallback. But it's easy enough to find a sans-serif typeface that's also easy to read all the individual letters in, and sans-serif fonts tend to be a bit easier to read at small text sizes, so I use one of those (a customized Iosevka) for most things on my laptop.