Comment by hackyhacky

Speaking as someone who has used both: yes. OBS is a general-purpose recording/streaming system. It gives you a lot of flexibility, but it can take some work to make things look "nice."

Screen Studio (and so OpenScreen as well) are "opinionated" and are designed to create aesthetic videos with minimal configuration. They can't do a lot of the things that OBS can do, but if all you want is to record your desktop with a webcam overlay, it's a lot easier.